Research Issues

Critical illness and medical crises are a huge drain on our society. They consume a disproportionate part of medical budgets and are tremendously disruptive to patients and their families. Due to the unpredictable nature of these issues, the heterogeneity of patients and the time critical nature of events, recruitment to clinical studies is difficult, and the results disappointingly noisy and unhelpful. There has thus developed a pressing need for a novel method to answer questions of crucial importance to these most vulnerable of patients.

What we are doing about ...

Ventilation strategies in the Intensive Care Unit

We are using complex, high-fidelity, multi-organ models to address ventilation strategies in the Intensive Care Unit, and their effects on gas exchange, ventilator-associated lung injury and tissue oxygen delivery. This work is currently funded by the MRC and is staffed by 2 post-doctoral researchers, 2 PhD students and 2 professors.

Critical illness resuscitation

We are using integrated multi-organ models to investigate the optimisation of critical illness resuscitation, including cardiopulmonary resuscitation (i.e. CPR), fluid resuscitation, ventilatory optimisation and the use of vasoactive drugs. This work is currently funded by the EPSRC and is staffed by 2 post-doctoral researchers, 1 PhD student and 2 professors.

Project Grants

The group has been awarded funding from both Medical Research Council(MRC) and Engineering and Physical Sciences Research Council(EPSRC).

  • £ 1.4M, EPSRC and Medtronic Ltd., "Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications", with Dr. Luigi Camporota, King’s College London, 2017-2021
  • £ 60K, Fisher & Paykel, Simulation investigation of the OptiFlow respiratory support system
  • £ 250K, Ministry of Defence, Simulation of battlefield pulmonary injuries and their management
  • £ 220K, Bayer Healthcare (Germany), Development of a pulmonary simulator, 2015-2017
  • £ 310K, MRC, “Integrated Cardiopulmonary Modelling for the Investigation of the Management of Disturbed Tissue Perfusion”, 2012-2015
  • £ 452K, EPSRC, “Development, Validation and Application of Population-based Pulmonary Disease Models using Robustness Analysis and Ensemble Forecasting”, 2011-2014
  • £ 432K, EPSRC, Systems Approaches to Well-Being Call, “Preventing Ventilator Associated Lung Injury using Feedback Control Engineering”, 2008-2011
  • £ 160K, EPSRC, Collaborating for Success in Systems Biology Discipline Hopping Award, “Improving the Clinical Applicability of Pathophysiological Modelling of Hypoxaemia using Robustness Analysis”, 2007-2008